September 17, 2025
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6 min

UTIs vs. Yeast Infections: How to Tell the Difference

You're dealing with uncomfortable symptoms down there, and Dr. Google has you convinced you have everything from a simple yeast infection to something way more serious.

We’ve all been there. But here's the truth: UTIs and yeast infections are two of the most common issues affecting women, but they're completely different conditions that need different treatments.

The frequency of uncomplicated cystitis in young sexually active women in the US is approximately 0.5 episodes per person per year, while approximately 70% of women report having had candidal vulvovaginitis in their lifetime. That's a lot of us dealing with these uncomfortable conditions, often trying to figure out which one we have through self diagnosis that doesn't always get it right.

At Twentyeight Health, we understand how frustrating it can be when you're experiencing symptoms and just want relief fast. That's why we offer Get Care Now — connecting you with providers who can quickly help determine whether you're dealing with a UTI vs yeast infection and get you the right treatment without the wait.

What is a UTI?

A urinary tract infection happens when bacteria — usually from your digestive system — make their way into your urinary tract. Think of it as unwanted bacteria setting up shop where they definitely don't belong.

How UTIs Happen

The most common culprit? E. coli bacteria from your bowel making the short trip from your anus to your urethra. Women are especially prone to UTIs because our anatomy makes this journey easier for bacteria — our urethra is shorter and closer to the genital area than in men.

Risk factors that increase your chances of getting a UTI include:

  • Sexual activity (bacteria can get pushed into the urethra)
  • Using certain feminine products like douches or scented feminine hygiene products
  • Not emptying your bladder completely
  • Wearing tight underwear that traps moisture
  • Having diabetes or other conditions affecting your immune system
  • Changes during pregnancy

UTI Symptoms: The Telltale Signs

When you have a UTI, the main symptom is usually that unmistakable burning sensation when you pee. But that's not all — UTI symptoms typically include:

  • Painful urination that feels like fire
  • Constant urge to pee, even when your bladder's empty
  • Pain or pressure in your lower abdomen or pubic bone area
  • Cloudy, dark, or bloody urine
  • Strong odor to your urine
  • Sometimes fever if the infection reaches your kidneys

One thing to remember about UTIs is the discomfort is mostly internal — in your bladder and urethra. If you're experiencing these symptoms, Get Care Now through Twentyeight Health can provide same-day treatment without the urgent care wait.


What is a Yeast Infection?

A vaginal yeast infection is a fungal infection caused by an overgrowth of candida fungus — specifically Candida albicans in most cases. Unlike UTIs, this isn't about bacteria invading from outside; it's about yeast that normally lives in your vagina growing out of control.

The Candida Connection

Here's what many women don't realize: Candida albicans are among the components of normal oral microflora, and around 30% to 50% of people carry this organism. It's supposed to be there! Problems only start when something throws off the delicate balance in your vagina, allowing the fungus to multiply.

Common triggers for yeast overgrowth include:

  • Antibiotics (they kill good bacteria that keep yeast in check)
  • High blood sugar levels
  • Hormonal changes during pregnancy or from birth control
  • Weakened immune system
  • Hot tubs and staying in wet clothes
  • Tight underwear or non-breathable fabrics

Yeast Infection Symptoms: External Irritation

Unlike UTIs, yeast infection symptoms are mostly external, affecting your vulva and vaginal area:

  • Intense vaginal itching and vulvar itching
  • Thick, white vaginal discharge (often described as cottage cheese-like)
  • Redness and swelling of the vulva
  • Pain during sex or when peeing (but different from UTI burning)
  • General irritation and soreness

The hallmark of a yeast infection is that maddening itch and the characteristic discharge. If these symptoms sound familiar, a provider through Twentyeight Health can help confirm your diagnosis and recommend treatment options.

Key Differences: UTI vs. Yeast Infection

Understanding the differences between these two conditions can help you get the right treatment faster:

Pain Location: Internal vs External

  • UTI: Pain is internal — in your bladder, urethra, and sometimes lower abdomen
  • Yeast: Discomfort is external — vulvar itching, irritation, and soreness

Discharge Differences

  • UTI: Usually no vaginal discharge
  • Yeast: Thick, white discharge is a key symptom

Urine Changes

  • UTI: Cloudy, dark, or bloody urine with strong odor
  • Yeast: Urine appearance typically normal

Burning Sensation

  • UTI: Burning sensation during urination is internal, in the urethra
  • Yeast: May have external burning, especially if skin is irritated

Risk After Antibiotics

  • UTI: Can happen anytime but not typically caused by antibiotics
  • Yeast: Often occurs after antibiotic based treatments for other conditions

When you're unsure which condition you're dealing with, Get Care Now providers can guide you to the right care without clinic delays.


Can You Have Both at the Same Time?

While it's possible to have both a UTI and yeast infection simultaneously, it's uncommon. However, here's where things get tricky: treating a UTI with antibiotics can sometimes lead to a yeast infection because the medication disrupts your vaginal flora.

Around 50—60% of women will experience a UTI in their lifetime, and many will then develop a yeast infection from the antibiotic treatment. It's a frustrating cycle that highlights why getting the right diagnosis from the start matters.

If you're experiencing overlapping symptoms, telehealth providers through Twentyeight Health can help distinguish between the two conditions and create a treatment plan that addresses your specific situation.

When to See a Doctor

While both conditions are common, certain red flags mean you need professional health care right away:

Seek immediate care if you have:

  • Fever or chills (could indicate kidney infection)
  • Blood in your urine
  • Severe back or side pain
  • Nausea or vomiting
  • Symptoms that don't improve with treatment
  • Recurring infections (more than 3 per year)

Don't wait days for an appointment when you're in discomfort. Get Care Now offers fast, private access to providers who understand these conditions and can prescribe the right treatment quickly.

Prevention Tips: Keeping Both at Bay

While you can't always prevent UTIs or yeast infections, these strategies can reduce your risk:

For Both Conditions:

  • Wipe from front to back after bowel movement
  • Avoid wearing tight underwear — choose breathable cotton
  • Change out of wet clothes quickly
  • Stay hydrated to flush your system
  • Limit time in hot tubs

UTI Prevention:

  • Pee before and after sex
  • Empty your bladder completely
  • Avoid feminine products that can irritate

Yeast Prevention:

  • Limit antibiotic use when possible
  • Manage blood sugar if you have diabetes
  • Avoid douching or scented feminine hygiene products
  • Consider probiotics to maintain healthy vaginal flora

How Twentyeight Health Can Help

UTIs and yeast infections might both cause discomfort down there, but they're distinct conditions requiring different treatments. UTIs are bacterial infections of your urinary tract causing internal burning and bladder symptoms. Vaginal yeast infections are fungal infections causing external itching and characteristic discharge.

Keep in mind that it’s dangerous to suffer in silence or rely on self diagnosis. One study found that 24% of college women with a first UTI experienced a recurrence within 6 months, often because the initial infection wasn't properly treated.

Whether you're dealing with that telltale burning sensation of a UTI or the maddening itch of a yeast infection, you deserve quick, effective treatment. Twentyeight Health's Get Care Now connects you with experienced providers who can accurately diagnose your condition and prescribe the right medication — all without leaving home.

Your health matters, and you shouldn't have to wait days for relief when effective treatment is just a click away. Skip the guessing game and get the care you need, when you need it — only at Twentyeight Health.



This article was medically reviewed by Twentyeight Health's clinical team.

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